解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::External ATP is believed to initiate and propagate Ca(2+) signals co-ordinating the insulin release pulses within and among the different islets in the pancreas. The possibility that islet endothelial cells participate in this process was evaluated by comparing the effects on [Ca(2+)](i) of purinoceptor activation in ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-9004-3
更新日期:2007-08-01 00:00:00
abstract::We have shown that gonadotrophs synthesize and secrete immunoreactive calcitonin (CT)-like peptide, and CT is a potent inhibitor of prolactin (PRL) secretion and gene transcription. CT cDNA cloned from LssT2 cells (pit-CT cDNA) exhibits 99% homology with mouse CT cDNA sequence, but exhibits four mismatches in the codi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0044-5
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:A promising radiopharmaceutical (99m)Tc-HYNIC-TOC ((99m)Tc-HYNIC-Octreotide) can be applied for somatostatin receptor scintigraphy with the potential to replace Indium-111 labeled somatostatin analogus. Here we evaluate whether orbital (99m)Tc-HYNIC-TOC scintigraphy can be used as a Graves' ophthalmopathy (GO...
journal_title:Endocrine
pub_type: 临床试验,杂志文章
doi:10.1007/s12020-007-0039-2
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves' disease (GD) and the susceptibility of K469E polymorphism to Graves' ophthalmopathy (GO) in Chinese population. STUDY DESIGN:A case-control and replication study was performed in 212 GD patients and 204 he...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0032-9
更新日期:2007-04-01 00:00:00
abstract::Thyrotrophin induces proliferation and function in thyroid cells acting through a seven transmembrane G protein-coupled receptor. The proliferative pathways induced by thyrotropin (TSH) in thyrocytes in vivo are not completely understood yet. The aim of this work is to evaluate if Ras can be induced by TSH in rat thyr...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0029-4
更新日期:2007-04-01 00:00:00
abstract::Previous evidence supports the view that insulin, as well as insulin like growth factor-1 (IGF-1) provides neurotropic support for neurons in the central nervous system (CNS) and peripheral nervous system (PNS). In the present study we evaluated the effects of the intravenous infusion of IGF-1 on both necrosis and apo...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-007-0012-0
更新日期:2007-02-01 00:00:00
abstract::Retinol binding protein 4 (RBP4) is a novel adipocyte-secreted protein that contributes to systemic insulin resistance. Experiments in mice suggest that elevated RBP4 causes insulin resistance. In the present study, we determined serum RBP4 concentration and evaluated its association with insulin resistance in women w...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-006-0006-3
更新日期:2006-12-01 00:00:00
abstract::The present study was designed to determine whether an association exists between HPA activity and cytokine production in major depression (MD). In 9 patients with MD and 11 control subjects of both sexes, all drug-free, activity of the HPA axis was evaluated by circadian rhythm of plasma cortisol, 24-h free urinary c...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1007/s12020-006-0016-1
更新日期:2006-12-01 00:00:00
abstract::The present study in female rats determined the effects of experimental hyperthyroidsm on hemorheological parameters and fibrinogen concentration. To induce experimental hyperthyroidism L-thyroxine (0.4 mg/100 g fodder) was added to the fodder of the experimental group rats for 20 d. After experimental duration, T3, T...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:30:2:203
更新日期:2006-10-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is significantly affected by environmental regulators impacting on genetic predisposition. Lifestyle changes can significantly modulate the phenotype of this disease. Diet, exercise, smoking, stress, and other factors adversely affect reproductive outcomes in PCOS. These influences can...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:30:1:35
更新日期:2006-08-01 00:00:00
abstract::Diabetes mellitus is complicated with the development of cardiac contractile dysfunction and electrical instability, which contributes to high morbidity and mortality in diabetic patients. This study examined the possible roles of enhanced endothelin-1 (ET-1) on diabetes-induced alterations in ventricular myocyte elec...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:30:1:121
更新日期:2006-08-01 00:00:00
abstract::Overproduction of proinflammatory factors is associated with obesity and diabetes. Interleukin (IL)-18 as a member of IL-1 cytokine family is increased in obese, in diabetic, and even in polycystic ovary syndrome (PCOS) patients. In the present study we evaluated the association of serum IL-18 levels with insulin resi...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:29:3:419
更新日期:2006-06-01 00:00:00
abstract::This study tested the hypothesis that aromatization of testosterone to estradiol is necessary for sexual differentiation of the sheep brain. Pregnant ewes (n = 10) were treated with the aromatase inhibitor 1,4,6- androstatriene-3,17-dione (ATD) during the period of gestation when the sheep brain is maximally sensitive...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:29:3:501
更新日期:2006-06-01 00:00:00
abstract::Increasing evidence suggests that inflammatory response may be a critical component of different brain pathologies. However, the role played by this reaction is not fully understood. The present findings suggest that neuroinflammtory mediators such as cytokines may be involved in a number of key steps in the pathologi...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:29:2:243
更新日期:2006-04-01 00:00:00
abstract::Hypoxia is a common neonatal stress that induces insulin resistance and a decrease in body weight gain. Dexamethasone is often used to treat neonatal cardiopulmonary disease, and also leads to insulin resistance and a decrease in body weight gain. The current study addressed the hypothesis that serum concentrations of...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:29:2:341
更新日期:2006-04-01 00:00:00
abstract::Aging can be defined as a progressive decline in the ability of the organism to resist stress, damage, and disease. Although there are currently over 300 theories to explain the aging phenomenon, it is still not well understood why organisms age and why the aging process can vary so much in speed and quality from indi...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:29:1:27
更新日期:2006-02-01 00:00:00
abstract::In the human and non-human primate the major secretory product of the uterine glandular epithelial cells is glycodelin. The expression of glycodelin is associated with elevated progesterone levels as its production peaks during the late luteal phase of the menstrual cycle and in early pregnancy. Consistent with our pr...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/endo:29:1:121
更新日期:2006-02-01 00:00:00
abstract::This article provides an overview of the increasing number of observations indicating that excitatory amino acids are involved in the control of prolactin secretion. The information available suggests that these amino acids exert a stimulatory action on hypophysial prolactin. Administration of a glutamate receptor ago...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:28:3:303
更新日期:2005-12-01 00:00:00
abstract::Concentrations of immunoreactive (ir-) inhibin in circulation, amniotic fluid, and testes of embryos and newly hatched ducks were determined from d 21 of incubation to d 1 of age. Plasma concentrations of FSH and LH were also determined by chicken radioimmunoassay (RIA) systems. In addition, gene expression and cellul...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:28:2:171
更新日期:2005-11-01 00:00:00
abstract::Many new techniques are rapidly being developed and applied to the study of normal and neoplastic pituitary. DNA microarrays are a uniquely efficient method for simultaneously assessing the expression levels of thousands of genes, identifying disease subphenotypes, and predicting disease progression. This article revi...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:28:1:049
更新日期:2005-10-01 00:00:00
abstract::The objectives of this study were to analyse the results of surgical treatment of multinodular goiter (MG) in a population with under 30 yr of age; (2) to determine the incidence and evolution of related thyroid carcinomas; and (3) to evaluate the rate of relapse. Eighty-one patients operated for MG and under 30 yr of...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:27:3:245
更新日期:2005-08-01 00:00:00
abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. It is characterized by a progressive loss of dopamine in the substantia nigra and striatum. However, over 70% of dopaminergic neuronal death occurs before the first symptoms appear, which makes either early diagnos...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:27:2:169
更新日期:2005-07-01 00:00:00
abstract::Environmental toxicants are thought to play a role in several estrogen-dependent diseases including breast cancer and endometriosis. Toxicant-induced increased aromatase activity, an enzyme complex that catalyzes the final rate-limiting step in the conversion of androgens to estrogens, has been reported in assays usin...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:27:1:045
更新日期:2005-06-01 00:00:00
abstract::Follicle-stimulating hormone (FSH) is a key stimulant for the development of the ovarian follicle, while luteinizing hormone (LH) plays a major role in triggering ovulation and luteinization. Both FSH and LH are glycoprotein hormones that share the same alpha subunit but bind to specific seven transmembrane-domain G c...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/endo:26:3:259
更新日期:2005-04-01 00:00:00
abstract::Chronic stress can have a deleterious effect on the re-productive axis that, for females, is manifested in an increased incidence of infertility. However, gonadal steroids may, in turn, affect a female's response to stress as measured by activity within the limbic-hypothalamic-pituitary-adrenal (LHPA) axis. What is no...
journal_title:Endocrine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1385/ENDO:26:2:089
更新日期:2005-03-01 00:00:00
abstract::Aging could be due to the accumulation of oxidative damage. On the other hand, growth hormone (GH) and estrogen deficiency induce deleterious effects on different tissues, and hormonal replacement could counteract these effects. We have investigated whether GH and estrogen administration modify some parameters related...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/endo:26:1:011
更新日期:2005-02-01 00:00:00
abstract::Homozygous Klotho mutant (kl-/-) mice exhibit a variety of phenotypes resembling human aging, including arteriosclerosis, infertility, skin atrophy, osteoporosis, and short life span. Calcium abnormality, one of the phenotypes in kl-/- mice, is thought to be due to the elevated gene expression of 25-hydroxyvitamin D3 ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:25:3:229
更新日期:2004-12-01 00:00:00
abstract::Diabetes with hypertension is characterized by increased cerebrovascular pathology and poorer outcomes following stroke. In this study we evaluated the effect of global brain ischemia on brain metabolic parameters in normal and diabetic rats treated with a dihydropyridine calcium antagonist, felodipine. Normal and dia...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:25:2:091
更新日期:2004-11-01 00:00:00
abstract::The present study investigates the effects of functional sensorial denervation, induced by administering capsaicin to hemiovariectomized adult female rats in each day of the estrus cycle, on ovulation and serum concentrations of estrogen and progesterone. The results indicate that the establishment of compensatory ova...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:25:2:155
更新日期:2004-11-01 00:00:00
abstract::The relationship among plasma levels of immunoreactive (ir)-inhibin, inhibin A, inhibin pro-alphaC, FSH, estradiol-17beta and follicular growth were investigated during the normal estrous cycle in mares. Seven mares were used for two successive normal estrous cycles. Follicular diameters and ovulation were obtained by...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:25:1:07
更新日期:2004-10-01 00:00:00
abstract::Quality of life (QoL) is an important aspect that reflects the way people feel and function. The assessment of QoL quality of life is an essential tool for estimating the efficacy of any therapy in different pathophysiological conditions. In normal, healthy women, the perception of QoL can be significantly modified du...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:24:3:231
更新日期:2004-08-01 00:00:00
abstract::Pituitary tumors are highly vascular neoplasms, which suggest an important role of angiogenesis in pituitary tumor growth. We used the human pituitary cell line (HP75) to examine the effects of the growth factors TGFbeta1, bFGF, and EGF on cell growth, and on the regulation of the pro-angiogenic growth factor VEGF-A a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:24:2:141
更新日期:2004-07-01 00:00:00
abstract::The alpha-subunit is common to the heterodimeric glycoprotein hormones and has been highly conserved throughout vertebrate evolution. In an effort to determine if wild-type and engineered human alpha analogs can serve as agonists or antagonists to the human thyroid-stimulating hormone (TSH) receptor (TSHR), a potent a...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:24:1:025
更新日期:2004-06-01 00:00:00
abstract::Erectile dysfunction (ED) is commonly associated with risk factors for cardiovascular disease, including diabetes. The prevalence of ED in diabetic patients is high--about 75% of diabetic men 60 yr of age or older had ED in one study. Endothelial dysfunction, accelerated atherosclerosis, and diabetic neuropathy likely...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:23:2-3:125
更新日期:2004-03-01 00:00:00
abstract::Follicle-stimulating hormone is synthesized and secreted as a mixture of heterogeneous isoforms that differ from each other in carbohydrate structure, biological potency, and plasma half-life. The relative abundance of the FSH isoforms will depend on the endocrine status of the donor at the time of sample collection. ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:23:2-3:189
更新日期:2004-03-01 00:00:00
abstract::Both osteoporosis and cardiovascular disease (CVD) are major public health problems leading to increased morbidity and mortality. Although traditionally viewed as separate disease entities that increase in prevalence with aging, accumulating evidence indicates that there are similar pathophysiological mechanisms under...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:23:1:01
更新日期:2004-02-01 00:00:00
abstract::The objective of this study was to assess the prevalence of macroprolactin, a macromolecule with reduced bioactivity, in hyperprolactinemic patients. Prolactin was measured before and after precipitation of macroprolactin by polyethylene glycol in 306 patients. Only patients with prolactin values >700 mIU/L (n = 270) ...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:22:3:267
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs). DESIGN AND METHODS:Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assesse...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:22:2:81
更新日期:2003-11-01 00:00:00
abstract::The study was performed to evaluate the prevalence of thyroid abnormalities detected by ultrasonography and, in particular, of multinodular nontoxic goiter in primary aldosteronism. We analyzed 80 consecutive of patients with primary hyperaldosteronism (40 with unilateral adenoma and 40 with idiopathic hyperaldosteron...
journal_title:Endocrine
pub_type: 杂志文章
doi:10.1385/ENDO:22:2:155
更新日期:2003-11-01 00:00:00
abstract::Fibromyalgia (FM) is a disease entity consisting of a heterogeneous cluster of symptoms that has thus far eluded identification of a causative etiology. The disease onset appears to follow physiological and/or psychological stressors and involves a subset of symptoms that are consistent with varied disorders found in ...
journal_title:Endocrine
pub_type: 杂志文章,评审
doi:10.1385/ENDO:22:1:67
更新日期:2003-10-01 00:00:00